Genprex

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Executive Summary

Genprex (NASDAQ : GNPX) is a clinical-stage biopharmaceutical company developing novel gene therapies to improve outcomes for cancer patients receiving promising targeted and immunotherapies, as well as to expand therapeutic benefits to a greater number of patients. The Company’s unique approach to cancer treatment is…

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Investor Presentation

This presentation may contain projections or other forward-looking statements regarding future events, the safety and efficacy of our product candidates, or the future financial performance of our company. These forward-looking statements may contain forward-looking words such as “may,” “might,” “should,”…

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Bibliography

A bibliography of selected publications describing technologies from Genprex.

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2019 AACR KRAS and LKB1 Poster – Meraz

The poster demonstrates research and data on the efficacy of novel immunogene-combinations for KRAS and LKB1 mutant NSCLC in a
humanized mouse model.

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2019 Nature Research Scientific Reports

MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.

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2019 AACR Hu-PDX Poster – Meraz

Development of an improved humanized patient-derived xenograft, Hu-PDX, mouse model for evaluation of antitumor immune response in lung cancer

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2017 AACR Poster – Meraz

TUSC2 (formerly known as FUS1, the active anti-cancer agent in OncoprexTM) in combination with PD-1 checkpoint inhibition has a significantly greater anti-tumor effect in lung cancer than either agent alone. The research also shows that TUSC2 in combination with PD-1 blockade has synergistic activity in upregulating natural…

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2012 AACR Poster – Yan

DNA alkylating agents such as platinum and nitrogen mustard are effective cancer chemotherapeutics. They kill proliferating tumor cells by inducing high levels of DNA damage leading to cell-cycle arrest and cell death. However, their highly toxic side effects and the common drug resistance exhibited in tumors limit their…

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2012 AACR Poster – Meng

TUSC2, a novel tumor suppressor gene in the human chromosome 3p21.3 region, is deleted in many cancers. A phase I clinical trial assessing TUSC2-mediated molecular therapy has reported antitumor activity in lung cancer patients. Previous studies showed that TUSC2 regulates the activation of multiple oncogenic kinases…

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2011 AACR Poster – Lu

A poster describing a phase I clinical trial investigating Oncoprex® (intravenous TUSC2 nanovesicles) used a single agent in recurrent, metastatic lung cancer patients. The dose escalation clinical trial was conducted at The University of Texas MD Anderson Cancer Center. The poster was presented at the 2011 Annual Meeting of…

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2011 AACR Abstract – Lu

An abstract describing a phase I clinical trial investigating Oncoprex® (intravenous TUSC2 nanovesicles) used a single agent in recurrent, metastatic lung cancer patients. The dose escalation clinical trial was conducted at The University of Texas MD Anderson Cancer Center. The abstract was published in the Proceedings of…

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